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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: The Id-protein family in developmental and cancer-associated pathways

Fig. 1

Control of DNA transcription by positive and negative HLH regulators. a Broadly expressed bHLH E proteins build heterodimers with tissue-specific bHLH proteins, which results in DNA binding at specific DNA sequences (in red) and DNA-transcription activation. b E-protein association with the Id proteins results in dimers with no ability to bind the DNA because the Id-protein subunit lacks the DNA binding region, which leads to inhibition of DNA-transcription activation. The helices of the HLH domains are represented by cylinders (grey for class I bHLH, orange for class II bHLH and magenta for Id); a blue-colored cylinder represents the basic DNA-binding region of the bHLH domain

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