Fig. 4

Experimental design suggests mTORC1 as second regulator of mTORC2. The model pools Red.ExpD1 and Red.ExpD2 are listed with the same classification option than Fig. 3 in Table (a) and (b), respectively. Table a shows the 310 models from the Red.pool that are in agreement with ExpD1, where all models contain PI3K and mTORC1 as essential regulators. The 634 model agreeing with ExpD2 and Red.pool are shown in Table b and do not show a clear tendency towards a second regulator. The graph shows the difference of the statistical analysis of Red.ExpD1 and the initial pool, visualizing the over-representation of PI3K and mTORC1 regulation on mTORC2 and an under-representation of RTK