Fig. 3

PI3K regulation on mTORC2 is present in every filtered model, but not in original pool. Statistical analysis of the reduced pool and initial pool for frequency F and impact I (correlation of components) was created with Tremppi and the graph shows the difference (reduced - full) for the Red.pool. PI3K regulation of mTORC2 is overrepresented in the reduced pool in both frequency and impact compared to the initial pool. The regulation by RTK and Tsc is less frequent in the filtered pool than in the full shown by dashed lines, yellow dotted lines show identical frequency and impact in both pools. The table shows the classification of all 994 models in the Red.pool according to the following features: Edges in the model, the data sets, and active hypotheses. Size gives the number of models in the class and the percentage of this class in the pool