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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: “Inverse signaling” of the transmembrane chemokine CXCL16 contributes to proliferative and anti-apoptotic effects in cultured human meningioma cells

Fig. 4

Binding of s-CXCL16 and signaling upon stimulation with s-CXCL16 depends on the tm-CXCL16 level. Expression of the tm-CXCL16 was reduced in human meningioma cells by siRNA targeting CXCL16 (for controls, an unspecific control siRNA was used). a Knockdown of CXCL16 yielded a drastically reduced binding signal of Cy3-labeled s-CXCL16 (upper part). Additionally, we observed reduced activation of the ERK signaling pathway as determined by Western blot on kinase phosphorylation (lower part). b The efficient knockdown of CXCL16 was determined by qRT-PCR (bottom right). Shown are 2 independent experiments with meningioma primary cultures from different donors

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