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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: “Inverse signaling” of the transmembrane chemokine CXCL16 contributes to proliferative and anti-apoptotic effects in cultured human meningioma cells

Fig. 3

s-CXCL16-mediated effects on proliferation and rescue from apoptosis. a 10 nM s-CXCL16 and 1 μg/ml αCXCL16 promote the proliferation of slowly growing human meningioma cells as measured by MTT activity assay. EGF (10 ng/ml) served as positive control. Control values were set 100 %, and shown are three independent experiments with cultures from different donors, with mean ± SD from 4 technical replicates. b When apoptosis was induced in human primary meningioma cells by 50 μg/ml camptothecin (Campto = 100 %), additional incubation with 10 nM CXCL16 could drastically reduce the caspase-3 activity. Shown are three independent experiments with cultures from different donors

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Cell Communication and Signaling

ISSN: 1478-811X