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Table 1 Histological analysis of the ErbB2/IRS2 bigenic tumors closely mirror ErbB2 single transgenic tumors

From: Lack of interaction between ErbB2 and insulin receptor substrate signaling in breast cancer

  ErbB2 ErbB2/IRS2
25 Tumors-18 mice 24 Tumors-17 mice
Histological Types
 Solid Adenocarcinoma 88 % (22/25) 66 % (16/24)
Differentiated
 Squamous Carcinoma 0 4 % (1/24)
 Adenosquamous Carcinoma 8 % (2/25) 21 % (5/24)
 Pillary 0 4 % (1/24)
  1. Histological analysis of nulliparous and parous tumors were combined for a total of 24 ErbB2/IRS2 bigenic tumors (18 mice) and 25 age-matched ErbB2 transgenic tumors (17 mice). All tumor phenotypes were scored by a pathologist based on H&E staining