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Table 1 Histological analysis of the ErbB2/IRS2 bigenic tumors closely mirror ErbB2 single transgenic tumors

From: Lack of interaction between ErbB2 and insulin receptor substrate signaling in breast cancer

 

ErbB2

ErbB2/IRS2

25 Tumors-18 mice

24 Tumors-17 mice

Histological Types

 Solid Adenocarcinoma

88 % (22/25)

66 % (16/24)

Differentiated

 Squamous Carcinoma

0

4 % (1/24)

 Adenosquamous Carcinoma

8 % (2/25)

21 % (5/24)

 Pillary

0

4 % (1/24)

  1. Histological analysis of nulliparous and parous tumors were combined for a total of 24 ErbB2/IRS2 bigenic tumors (18 mice) and 25 age-matched ErbB2 transgenic tumors (17 mice). All tumor phenotypes were scored by a pathologist based on H&E staining