Fig. 5From: A new mode of SAM domain mediated oligomerization observed in the CASKIN2 neuronal scaffolding proteinThe linker interface in the CASKIN2 SAM tandem dimer. As observed in the crystal structure of the domain swapped dimer, SAM1 and SAM2 are restrained by intra- and intermolecular hydrophobic interactions between W554 and Y558 (orange) in the linker region. This central interface is further defined by an ionic interaction between E565 (red) and R618 (blue)Back to article page