Fig. 5

a MCF-7 cells and RFP-MSC (untreated or cisplatin pretretreated) were co-cultured for 5 days and subsequently sorted according to expression of fluorescent marker. Gene expression array of 84 genes revealed statistically significant downregulation or upregulation of several genes (shown in table). b We evaluated the effect of MSC-secreted factors also in vivo. Tumor bearing mice were treated with cisplatin (3 mg/kg) alone or in combination with 250.000 of MSC. MSC were administered i.v. in the same day as chemotherapy. We found that administration of MSC reduced the therapeutic effect of cisplatin