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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells

Fig. 4

a MDA-MB-231 NucLight Red™ cells were treated with cisplatin (0.5 μg/ml) diluted in standard culture medium with/without 50 ng/ml IL-6, IL-8, or both. The cytokines IL-6 and IL-8 were able to increase the resistance of MDA-MB-231 NucLight Red™ cells to cisplatin. b Flow cytometry ALDEFLUOR® Assay has revealed increased ALDH activity in both MDA-MB-231 (10.8 % vs. 0.54 %) and MCF-7 cells (8.78 % vs. 4.46 %) cultivated in conditioned medium from pre-exposed MSC in comparison to tumor cells cultivated in control CM

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