Fig. 4
From: GPR91: expanding the frontiers of Krebs cycle intermediates
GPR91 activation induces retinal neovascularization in ischemic proliferative retinopathy. Under normal conditions, retina presents a basal vascularization. (1) During hypoxia, succinate accumulates and (2) binds to GPR91 on RGCs, leading to (3) proangiogenic factor production that stimulate the development of new vessels (4) in order to restore the vascular supply to the hypoxic retina