From: Phase separation in biology; functional organization of a higher order
Organelle | Biological role | Protein | Domains/Motifs | RNA |
---|---|---|---|---|
Nucleolus | Ribosome biogenesis in nucleus | Fibrillarin | RGG box [133] | rRNA [8] |
Nucleolin | RRMs; RGG box [67] | |||
Paraspeckles | Regulation of gene expression in nucleus | PSPC1 | RRMs; Coil [2] | |
NONO/P54NRB | RRMs; Coil [2] | |||
SFPQ/PSF | RRMs; Coil [2] | |||
Nuclear speckles | Regulation of gene expression via storage of splicing factors | SRSF1 | RRMs; RS [134] | |
Cajal bodies | Regulation of snRNP maturation | Coilin | Coiled-coil [23] | |
SMN | Coiled-coil [23] | |||
PML bodies | Regulation of transcription and protein storage | PML | Coiled-coil [12] | |
Germ granules | Regulation of mRNA translation in the cytoplasm of germ cells | GLH-1, GLH-2, GLH-4 | FG [74] | Developmentally regulated maternal mRNAs (nos-1, pos-1, mex-1, skn-1 , gld-2) [74, 136] |
PGL-1, PGL-3 | RGG [63] | |||
DDX4 | FG; RG [48] | |||
LAF-1 | RGG box [47] | |||
P bodies | mRNA processing and decay | Pdc1 | HLM; Coiled-coil [49] | mRNA [31] |
Dcp2 | HLM [49] | |||
Edc3 | LSm; FDF [49] | |||
Stress granules | Storage of translationally stalled mRNA and proteins of the translational machinery | FUS | Poly-(A)+ mRNA associated with PABP [30] | |
hnRNPA1 | RRM; RGG box; [G/S]Y[G/S] [50] |