Fig. 4

Multiple Sequence Alignment detail for the C-termini of LAT proteins. The three most conserved regions are the critical YxN motifs that bind the GRB2/GADS SH2 domains (see Fig. 1), to assemble the signalling complex. The residue colours are Clustal defaults with less conserved positions faded. LAT protein sequences from representative species were aligned with Clustal Omega [49]. Figure prepared with Jalview [48]