Hydrogen peroxide – production, fate and role in redox signaling of tumor cells

Table 3 Current therapeutic strategies for the treatment of cancer patients to trigger ROS-mediated cell death

substance	target/mechanism	treatment of
Auranofin	TrxR inhibitor	leukemia, solid cancer, melanoma [213]
+ BSO	inhibition of GSH biosynthesis	head and neck cancer cells, malignant B cells [215, 216]
+ Selenocystin		lung cancer [214]
MJ25	TrxR inhibitor	melanoma [213]
Imexon	prooxidant, cysteine depletion	B cell non-Hodgkin lymphoma [243, 244]
Calmangafodipin	SOD mimetica	metastatic colorectal cancer [245]
Molexafin gadolinum	TrxR inhibitor, superoxide formation	glioblastoma multiform [246]
Arsenic trioxide	inhibitor of mitochondrial chain, GPx and TrxR	melanoma [247]
+ GSH depletion	inhibitor of mitochondrial chain, GPx and TrxR	melanoma [247]

ISSN: 1478-811X