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Table 2 Redox-sensitive proteins involved in the regulation of cell metabolism, angiogenesis and cell death

From: Hydrogen peroxide – production, fate and role in redox signaling of tumor cells

protein category modificationa cysteine residue effect
anti-oxidative defense-related redox sensors
 Keap1 others S-S C151 inactivation [238]
 2-cys Prx peroxidase sulfonic acid C51 inactivation [239]
 Trx others S-S C32/C35 inactivation [240]
metabolism-related redox sensors
 AMPK kinase G C299, C304 activation [241]
S-S C130, C174 inactivation [132]
 ATM kinase S-S C2291 activation [138, 142]
 PKM2 kinase   C358 inactivation [146]
angiogenesis-related redox sensors
 VEGFR receptor S-S C1206/C1199 inactivation [147, 148]
 LMW-PTP phosphatase S-S C12/C17 inactivation [242]
 SENP3 sumo   C243 and/or C274 stabilization [158]
  protease   C243 HIF-1 transactivation [160, 161]
    C532 inactivation, suppressed HIF-1 activity [160, 161]
 Lyn kinase   C466 recruitment of leukocytes [168, 169]
 PKG kinase S-S C42 activation [172]
cell death-related redox sensors
 ASK1 kinase S-S C250 inactivation [178, 179]
 Fas receptor G C294 aggregation, FasL binding [186]
 FOXO4 TF S-S C477 inactivation [189]
 HMGB1 others S-S C23/C45 induction of apoptosis [193]
 CFL others S-S, G C139/C147, C39/C80 inactivation, inhibition of apoptosis [208210]
  1. a C cysteine, S-S intra-/intermolecular disulfide, G glutathionylation