Hydrogen peroxide – production, fate and role in redox signaling of tumor cells

Table 2 Redox-sensitive proteins involved in the regulation of cell metabolism, angiogenesis and cell death

protein	category	modification^a	cysteine residue	effect
anti-oxidative defense-related redox sensors
Keap1	others	S-S	C151	inactivation [238]
2-cys Prx	peroxidase	sulfonic acid	C51	inactivation [239]
Trx	others	S-S	C32/C35	inactivation [240]
metabolism-related redox sensors
AMPK	kinase	G	C299, C304	activation [241]
AMPK	kinase	S-S	C130, C174	inactivation [132]
ATM	kinase	S-S	C2291	activation [138, 142]
PKM2	kinase		C358	inactivation [146]
angiogenesis-related redox sensors
VEGFR	receptor	S-S	C1206/C1199	inactivation [147, 148]
LMW-PTP	phosphatase	S-S	C12/C17	inactivation [242]
SENP3	sumo		C243 and/or C274	stabilization [158]
	protease		C243	HIF-1 transactivation [160, 161]
			C532	inactivation, suppressed HIF-1 activity [160, 161]
Lyn	kinase		C466	recruitment of leukocytes [168, 169]
PKG	kinase	S-S	C42	activation [172]
cell death-related redox sensors
ASK1	kinase	S-S	C250	inactivation [178, 179]
Fas	receptor	G	C294	aggregation, FasL binding [186]
FOXO4	TF	S-S	C477	inactivation [189]
HMGB1	others	S-S	C23/C45	induction of apoptosis [193]
CFL	others	S-S, G	C139/C147, C39/C80	inactivation, inhibition of apoptosis [208–210]

ISSN: 1478-811X