From: Hydrogen peroxide – production, fate and role in redox signaling of tumor cells
target | name | relation to cancer |
---|---|---|
Trx1 | thioredoxin 1 | proto-oncogene expressed in many cancers [224] |
elevated serum levels in patients with ovarian cancer [225] | ||
overexpression in HCC, CRC, liver metastasis [224] and | ||
in breast cancer [226] | ||
TrxR1 | thioredoxin reductase1 | overexpressed in many cancer cells and cell lines of distinct histology [227] |
TXNIP | thioredoxin interacting protein | negatively interferes with bladder carcinogenesis [228] |
tumor suppressor in thyroid cancer [229] | ||
Prx1 | peroxiredoxin 1 | increased expression in pancreatic cancer [230], breast cancer [226, 231] and HCC [232] |
promotion of lung cancer progression [233] | ||
related to tumor angiogenesis in pancreatic cancer [230] | ||
Prx6 | peroxiredoxin 6 | promotion of lung tumor growth [234, 235] repressed expression in papillary thyroid carcinomas [236] |
Srx | sulfiredoxin | oncogenic role in skin tumorigenesis [237] |
overexpression in squamous cell carcinoma [56] | ||
promotion of lung cancer progression [69] |