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Table 1 Nrf2 targets and their correlation to cancer

From: Hydrogen peroxide – production, fate and role in redox signaling of tumor cells

target name relation to cancer
Trx1 thioredoxin 1 proto-oncogene expressed in many cancers [224]
elevated serum levels in patients with ovarian cancer [225]
overexpression in HCC, CRC, liver metastasis [224] and
in breast cancer [226]
TrxR1 thioredoxin reductase1 overexpressed in many cancer cells and cell lines of distinct histology [227]
TXNIP thioredoxin interacting protein negatively interferes with bladder carcinogenesis [228]
tumor suppressor in thyroid cancer [229]
Prx1 peroxiredoxin 1 increased expression in pancreatic cancer [230], breast cancer [226, 231] and HCC [232]
promotion of lung cancer progression [233]
related to tumor angiogenesis in pancreatic cancer [230]
Prx6 peroxiredoxin 6 promotion of lung tumor growth [234, 235] repressed expression in papillary thyroid carcinomas [236]
Srx sulfiredoxin oncogenic role in skin tumorigenesis [237]
overexpression in squamous cell carcinoma [56]
promotion of lung cancer progression [69]
  1. CRC colorectal carcinoma, HCC hepatic cell carcinoma
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