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Table 1 Nrf2 targets and their correlation to cancer

From: Hydrogen peroxide – production, fate and role in redox signaling of tumor cells

target

name

relation to cancer

Trx1

thioredoxin 1

proto-oncogene expressed in many cancers [224]

elevated serum levels in patients with ovarian cancer [225]

overexpression in HCC, CRC, liver metastasis [224] and

in breast cancer [226]

TrxR1

thioredoxin reductase1

overexpressed in many cancer cells and cell lines of distinct histology [227]

TXNIP

thioredoxin interacting protein

negatively interferes with bladder carcinogenesis [228]

tumor suppressor in thyroid cancer [229]

Prx1

peroxiredoxin 1

increased expression in pancreatic cancer [230], breast cancer [226, 231] and HCC [232]

promotion of lung cancer progression [233]

related to tumor angiogenesis in pancreatic cancer [230]

Prx6

peroxiredoxin 6

promotion of lung tumor growth [234, 235] repressed expression in papillary thyroid carcinomas [236]

Srx

sulfiredoxin

oncogenic role in skin tumorigenesis [237]

overexpression in squamous cell carcinoma [56]

promotion of lung cancer progression [69]

  1. CRC colorectal carcinoma, HCC hepatic cell carcinoma