Fig. 6
From: Hydrogen peroxide – production, fate and role in redox signaling of tumor cells
Components of anti-oxidative systems involved in tumor development. Cancer cells are characterized by high levels of ROS (H2O2). To prevent cell damage and cell death cancer cells induce the expression of anti-oxidative enzymes via the activation of the transcription factor Nrf2. Despite high H2O2 levels cancer cells maintain the capacity to promote cell survival, differentiation and proliferation by undergoing metabolic adaption processes thereby relying on the redox regulation of cancer-related redox sensors.