Method | Peptide library size | Pros | Cons |
---|---|---|---|
Combinatorial phage display | 1010 | Library size | No PTMs, various biases |
ProP-PD | 104–-106 | Unbiased | No PTMs |
Yeast surface display | 108 | Some PTMs, unbiased | Limited library size |
Peptide array | 102 – 103 | PTMs, semi-quantitative | Limited coverage |
Biased library | |||
Cost of materials | |||
High-density array | 105 – 106 | Coverage | Cost of materials |
Protein microarray | 10–100 s | Semi-quantitative | Protein stability |
Labor intense set-up | |||
Y2H | 106 | Low tech | No PTMs |