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Table 1 Examples of interactions between modular domains and linear motifs

From: High-throughput methods for identification of protein-protein interactions involving short linear motifs

Protein

Domain

Consensus motif

Target protein/binding peptide

Function

Reference

GRB2

SH2

pY-x-(E/N)

ERBB3/pYMN

Ras signaling

[93]

GRB2

SH3

P-x-x-P-x-(R/K)

SOS1/PPVPPR

Ras signaling

[94]

SUMO1

SUMO

(V/I/L)-(V/I/L)-(D/E)-(V/I/L)

PIAS1/VIDL

Sumoylation

[66]

SDCBP

PDZ

Φ-x-Φ-coo-

SDC1/EFYA-coo-

Trafficking

[95]

YAP1

WW

PP-x-Y

TP73/PPPY

Transcriptional regulation

[96]

  1. “Φ” indicates a hydrophic residue and “x” any amino acid
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Cell Communication and Signaling

ISSN: 1478-811X