Fig. 2
From: Orai/CRACM1 and KCa3.1 ion channels interact in the human lung mast cell plasma membrane
FcεRI- and 1-EBIO-dependent HLMC KCa3.1 currents are attenuated by an Orai channel blocker. a KCa3.1 currents induced following FcεRI-dependent activation are attenuated in HLMCs following addition of the Orai channel blocker GSK-7975A (n = 27 cells). b KCa3.1 currents induced following 1-EBIO-dependent activation are attenuated following addition of the Orai channel blocker GSK-7975A (n = 29 cells). Data presented as mean ± SEM. c Overexpressed KCa3.1 channels in HLMCs were constitutively active and were not blocked by GSK-7975A (1 μM)(n = 4 cells, p = 0.43 at +40 mV)