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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways

Fig. 2

The role of CagA in p53 regulation. a. CagA phosphorylation and activation of HDM2 is mediated by Akt or ERK activation. b. CagA plays a crucial role in p53 shifting to inhibitory p53 isoforms. c. CagA-induced hypermethylation of the p14ARF promoter results in a decrease in p14ARF protein levels that is not sufficient to sequester HDM2 in the nucleus. d. CagA interacts with ASPP2 to recruit and bind p53, which is then degraded by the proteasome. e. CagA induces aberrant expression of AID via NF-κB and thereby elicits a high mutation frequency in p53

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