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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways

Fig. 1

CagA mediates dysregulation of the Wnt/β-catenin signaling pathway. a. CagA competitively combines with E-cadherin and disrupts the E-cadherin/β-catenin complex formation, causing cytoplasmic and nuclear accumulation of β-catenin. b. H. pylori induces rapid phosphorylation and activation of LRP6. c. CagA induces GSK-3β inactivation via the PI3K/Akt signaling pathway. d. CagA binds GSK-3β directly and depletes GSK-3β activity, inhibiting the phosphorylation and proteasomal degradation of cytosolic β-catenin

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Cell Communication and Signaling

ISSN: 1478-811X