Skip to main content

Table 2 Emax of ACh-induced relaxations during PHE-induced contractions in presence or absence of INDO, L-NAME or a combination of the former

From: Endothelial Connexin37 and Connexin40 participate in basal but not agonist-induced NO release

 

Emax (mean (% relaxation) ± SEM)

 

WT

Cx37−/−

Cx40−/−

Cx40+/−

Control

51 ± 9

50 ± 7

47 ± 7

50 ± 9

INDO

83 ± 5***

63 ± 12

71 ± 8*

98 ± 3**

L-NAME

−11 ± 2***

−8 ± 6***

6 ± 4***

−8 ± 4***

L-NAME + INDO

4 ± 2***

6 ± 5***

2 ± 3***

3 ± 16**

  1. N = 6–10. *, ** or *** p < 0.05, 0.01 or 0.001 vs control