Table 1 Characteristics of PHE-induced contractions in presence or absence of L-NAME
From: Endothelial Connexin37 and Connexin40 participate in basal but not agonist-induced NO release
Emax (mean (mN) ± SEM) | EC50 (mean (nM) 95 % CI) | |||||||
|---|---|---|---|---|---|---|---|---|
WT | Cx37−/− | Cx40−/− | Cx40+/− | WT | Cx37−/− | Cx40−/− | Cx40+/− | |
Control | 3.1 ± 0.2 | 4.0 ± 0.5 $$$, §§§ | 6.0 ± 0.5 $$$ | 1.9 ± 0.4 §§§ | 91 95 % CI [57, 145] | 48 95 % CI [25, 94] | 39 95 % CI [20, 78] | 84 95 % CI [24, 291] |
L-NAME | 4.1 ± 0.3*** | 3.7 ± 0.6 | 4.9 ± 0.9 | 3.7 ± 0.7*** | 39 95 % CI [24, 62] | 24 95 % CI [5, 115] | 26 95 % CI [12, 57] | 37 95 % CI [8, 160] |