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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Endothelial Connexin37 and Connexin40 participate in basal but not agonist-induced NO release

Fig. 5

Cx37 may be implicated in the release of COX products but not in activated NO release. Concentration-response curves for the endothelium-specific agonist ACh were generated in PHE pre-contracted aortas obtained from WT, Cx37−/−, Cx40−/− or Cx40+/− mice. a WT aortas displayed relaxations in response to ACh (black) which were i) increased in presence of INDO (blue) and ii) inhibited in presence of L-NAME (red) or in presence of L-NAME and INDO (green). b Cx37−/− aortas displayed relaxation responses to ACh (black) which were i) unaffected by presence of INDO (blue), ii) inhibited in presence of L-NAME (red) or in presence of L-NAME and INDO (green). c Aortas obtained from Cx40−/− mice (c) displayed relaxations in response to ACh (black) which were i) slightly, but significantly, increased in presence of INDO (blue) and ii) inhibited in presence of L-NAME (red) or in presence of L-NAME and INDO (green). d Aortas obtained from Cx40+/− mice displayed relaxations in response to ACh (black) which were i) increased in presence of INDO (blue) and ii) inhibited in presence of L-NAME (red) or in presence of L-NAME and INDO (green). Values are expressed as mean ± SEM. N = 6–10. *, ** or *** p < 0.05, 0.01 or 0.001 vs. control, respectively

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