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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells

Fig. 1

CDCA induced ATP release from exocrine pancreatic cells. The time-course of ATP release from Capan-1 cells in response to 0.3 and 1 mM of (a) GCDCA and (b) TCDCA (n = 4, 4). The time-course of ATP release from (c) Capan-1 and (e) AR42J after stimulation with 0.3 and 0.5 mM CDCA, respectively (n = 6, 5). Dose-dependent release of ATP from (d) Capan-1 and (f) AR42J cells in response to CDCA (n = 5, 6). The EC50 values of ATP release from AR42J and Capan-1 are 0.44 mM (pEC50 = 3.36 ± 0.03) and 0.43 mM (pEC50 3.36 ± 0.04) (n = 5, 6) respectively in the range of 0.1 – 1 mM CDCA. Y-axis shows ATP concentrations, which were corrected for 106 cells per 1 ml (see Methods). Data shown as mean values ± SEM. Arrows indicate addition of stimulants

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