Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines

Table 2 Signalling pathway components showed variable levels of transcriptional disruption to their local interactome

Rank	HGNC symbol	degree	Rank	HGNC symbol	degree	Rank	HGNC symbol	degree
1	HSP90AA1	164	11	PIK3R1	66	21	ERBB2	42
2	HSP90AB1	132	12	VCP	59	22	TGFBR1	41
3	EGFR	122	13	CALM1	58	23	HSPA1A	39
4	MYC	99	14	TUBB	57	24	RAC1	38
5	GSK3B	84	15	LYN	49	25	PIN1	37
6	FYN	76	16	JUN	48	26	NFKB1	37
7	ABL1	70	17	GAPDH	47	27	CDK6	35
8	PRKACA	68	18	FOS	45	28	MAPK3	35
9	PRKCA	67	19	CREBBP	45	29	TK1	34
10	CDK1	67	20	TUBA1A	42	30	PSMA7	34

mRNA transcripts encoding proteins for which there are drugs, inhibitors or antagonists available (through DrugBank v3.0), ranked by degree within a protein-protein interaction network of differentially expressed transcripts. Degree reflects the number of interaction partners (for the encoded protein) which show significant changes in transcript abundance.

ISSN: 1478-811X