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Table 2 Signalling pathway components showed variable levels of transcriptional disruption to their local interactome

From: Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines

Rank HGNC symbol degree Rank HGNC symbol degree Rank HGNC symbol degree
1 HSP90AA1 164 11 PIK3R1 66 21 ERBB2 42
2 HSP90AB1 132 12 VCP 59 22 TGFBR1 41
3 EGFR 122 13 CALM1 58 23 HSPA1A 39
4 MYC 99 14 TUBB 57 24 RAC1 38
5 GSK3B 84 15 LYN 49 25 PIN1 37
6 FYN 76 16 JUN 48 26 NFKB1 37
7 ABL1 70 17 GAPDH 47 27 CDK6 35
8 PRKACA 68 18 FOS 45 28 MAPK3 35
9 PRKCA 67 19 CREBBP 45 29 TK1 34
10 CDK1 67 20 TUBA1A 42 30 PSMA7 34
  1. mRNA transcripts encoding proteins for which there are drugs, inhibitors or antagonists available (through DrugBank v3.0), ranked by degree within a protein-protein interaction network of differentially expressed transcripts. Degree reflects the number of interaction partners (for the encoded protein) which show significant changes in transcript abundance.