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Table 1 Different signalling pathways are dysregulated between the models of in vitro induced EMT

From: Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines

differential analysis between: Cell Lines PMC42-ET PMC42-LA MDA-MB-468 MDA-MB-468 PMC42-ET vs. PMC42-LA PMC42-ET vs. PMC42-LA MDA-MB-468
Conditions +EGF vs. Unstim. +EGF vs. Unstim. +EGF vs. Unstim. +HPX vs. Unstim. Unstim. +EGF +HPX vs +EGF
  number of differentially expressed transcripts 238 591 3155 3716 3261 2938 1626
KEGG signalling pathway/system: PI3K-Akt 0.015 0.000 0.030 0.005 0.153 0.559 0.943
HIF-1 0.952 0.244 0.002 0.002 0.982 0.732 0.000
Rap1 0.562 0.014 0.000 0.000 0.175 0.075 0.742
Hippo 0.173 0.000 0.022 0.085 0.004 0.297 0.996
Wnt 0.015 0.371 0.038 0.071 0.002 0.455 0.534
MAPK 0.214 0.044 0.312 0.680 0.360 0.634 0.768
Hedgehog 0.977 0.000 0.999 0.939 0.217 0.093 0.993
TGF-beta 0.029 0.000 0.215 0.328 0.053 0.632 0.694
Ras 1.000 0.169 0.259 0.022 0.120 0.065 0.783
Phosphatidyl-inositol 0.796 0.833 0.238 0.049 0.753 0.923 0.893
cAMP 0.992 0.639 0.242 0.017 0.983 0.756 0.201
  1. The first row shows the number of mRNA transcripts with a significant (q-value < 0.05) difference in abundance between the specified cell lines or conditions. Subsequent rows show the estimated p-value for enrichment of elements within KEGG pathways without correction for multiple hypothesis testing. KEGG maps related to signal transduction with a significant (p-value < 0.05) enrichment in at least one comparison are shown (for a complete list please refer to Additional file 8: Table S2). Values in bold are statistically-significant following a Bonferroni correction for multiple hypothesis testing (adjusted p-value < 0.05; n = 22 ‘signalling pathway’ KEGG maps), p-value entries greater than 0.10 are in grey.