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Figure 2 | Cell Communication and Signaling

Figure 2

From: Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines

Figure 2

Numerous signalling components showed significant differences between EGF and HPX mediated EMT. Heat maps for: (a) mRNA transcripts for signalling components which are present across at least six perturbed signalling pathway KEGG maps (Table 1); (b, c) mRNA transcripts with significant (q-value < 0.05) differences in mRNA transcript abundance within at least one PMC42 cell line condition comparison, and differences in mRNA transcript abundance going in (b) the same, or (c) different directions for EGF or HPX-stimulated MDA-MB-468 cells compared to unstimulated, with a significant difference in transcript abundance between the EGF- and HPX-stimulated MDA-MB-468 cells. Membership within KEGG maps that are listed in Table 1 is shown at right (black box). Note the use of alternative colour-bars to indicate statistically significant (**; q-value < 0.05; red-green) and non-significant (brown/orange-teal) changes in abundance.

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