Figure 9From: Constitutive activation of oncogenic PDGFRα-mutant proteins occurring in GIST patients induces receptor mislocalisation and alters PDGFRα signalling characteristics Model recapitulating the localisation-dependent divergent signalling capacities of wild-type PDGFRα and the different pools of mutant PDGFRα proteins. *It is currently not clear whether mutant PDGFRα proteins exist in a monomeric or dimeric state.Back to article page