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Figure 8 | Cell Communication and Signaling

Figure 8

From: Constitutive activation of oncogenic PDGFRα-mutant proteins occurring in GIST patients induces receptor mislocalisation and alters PDGFRα signalling characteristics

Figure 8

Mutant receptors show increased expression of known STAT target genes. Heat map showing the log2-transformed fold change of selected known STAT target genes in our microarray experiments for the PDGF-AA stimulated PDGFRα-wt and the oncogenic mutants. Conditions for which the genes showed no statistically significant alteration in expression level were coloured in grey (step-up FDR > 0.05).

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