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Table 3 Overview of the top 5 significantly enriched Gene Ontology biological processes in the 6 clusters of significantly differentially expressed genes during conditions of parabolic flight

From: Differential gene expression of human chondrocytes cultured under short-term altered gravity conditions during parabolic flight maneuvers

Cluster

GO ID

Process

p-value

Genes represented

1

GO:0045449

regulation of transcription

6.08*10−8

HMGB1, SBNO2, ELF4, FOXO1, NFKB2, TRIB1, LIF, TSC22D1, HEXIM1, ZNF697, PER2, SIK1, SERTAD2, NFATC1, MAFG, BMP2, EGR2, CEBPB, KLF9, KLF13, RELB, LOC100131261, PURB, FOXN3, SOD2, PTHLH, NOTCH2, PHF1, ETS1, JMJD6, VEGFA, ERN1, FOXC2, HABP4, ZBTB2, NCOR2

GO:0051252

regulation of RNA metabolic process

1.59*10−7

HMGB1, SBNO2, ELF4, FOXO1, MAPKAPK2, NFKB2, LIF, TSC22D1, HEXIM1, PER2, SIK1, NFATC1, SERTAD2, MAFG, BMP2, EGR2, CEBPB, KLF9, KLF13, RELB, FOXN3, PURB, SOD2, NOTCH2, JMJD6, ETS1, VEGFA, FOXC2, NCOR2

GO:0006355

regulation of transcription, DNA-dependent

1.48*10−6

HMGB1, SBNO2, ELF4, FOXO1, NFKB2, LIF, TSC22D1, HEXIM1, PER2, SIK1, NFATC1, SERTAD2, MAFG, BMP2, EGR2, CEBPB, KLF9, KLF13, RELB, FOXN3, PURB, SOD2, NOTCH2, ETS1, VEGFA, FOXC2, NCOR2

GO:0006357

regulation of transcription from RNA polymerase II promoter

8.69*10−6

HMGB1, BMP2, EGR2, CEBPB, KLF9, ELF4, KLF13, FOXO1, SOD2, LIF, ETS1, HEXIM1, VEGFA, FOXC2, SIK1, NCOR2

GO:0006350

transcription

1.09*10−5

SBNO2, ELF4, FOXO1, NFKB2, TSC22D1, HEXIM1, ZNF697, PER2, NFATC1, SERTAD2, MAFG, EGR2, CEBPB, KLF9, KLF13, RELB, FOXN3, LOC100131261, PURB, NOTCH2, PHF1, JMJD6, ETS1, ERN1, HABP4, FOXC2, ZBTB2, NCOR2

2

GO:0045449

regulation of transcription

6.34*10−4

TXNIP, ZNF84, RCOR2, PPM1A, NFYA, ZNF514, ZNF512, MEN1, LHX2, ZNF239, ZNF471, ZNF599, THAP11, RNF14

GO:0006350

transcription

1.44*10−3

TXNIP, ZNF84, RCOR2, LHX2, ZNF239, ZNF471, ZNF599, NFYA, ZNF514, THAP11, ZNF512, RNF14

GO:0007498

mesoderm development

9.48*10−3

NUP133, OSR1, LHX2

GO:0006355

regulation of transcription, DNA-dependent

1.90*10−2

MEN1, ZNF84, LHX2, PPM1A, ZNF471, ZNF599, NFYA, ZNF514, RNF14

GO:0051252

regulation of RNA metabolic process

2.16*10−2

MEN1, ZNF84, LHX2, PPM1A, ZNF471, ZNF599, NFYA, ZNF514, RNF14

3

GO:0045449

regulation of transcription

8.41*10−3

DPF2, ZBTB22, EID2B, ZNF451, ZNF25, BANP, ZKSCAN1, ZNF514, UBN1, NR2C1, PIAS4, PRMT6, BAZ2B, TIGD7, IRAK1BP1

GO:0006350

transcription

1.01*10−2

DPF2, ZBTB22, EID2B, ZNF451, ZNF25, BANP, ZKSCAN1, ZNF514, NR2C1, PIAS4, PRMT6, BAZ2B, IRAK1BP1

4

None

   

5

GO:0006350

transcription

2.75*10−5

ERF, EGR3, ELL, NR4A2, C14ORF43, ZNF16, MEF2D, CRY2, NAB2, MNT, SERTAD3, BCL3, PER1, RARA, VGLL4, CHD6, NFIL3, SERTAD1

GO:0045449

regulation of transcription

3.01*10−5

ERF, EGR3, ELL, NR4A2, ZNF16, C14ORF43, DLX3, MEF2D, CRY2, ID1, NAB2, MNT, SERTAD3, BCL3, PER1, RARA, VGLL4, CHD6, NFIL3, SERTAD1

GO:0032680

regulation of tumor necrosis factor production

3.57*10−3

NOD1, BCL3, RARA

GO:0048511

rhythmic process

5.90*10−3

EGR3, CRY2, PER1, NFIL3

GO:0007623

circadian rhythm

7.74*10−3

EGR3, CRY2, PER1

6

GO:0006916

anti-apoptosis

1.66*10−5

CSF2, IER3, MCL1, HIPK3, NFKBIA, IL1B, TNFAIP3, BIRC3

GO:0043066

negative regulation of apoptosis

7.39*10−5

CSF2, IER3, IL6, MCL1, HIPK3, NFKBIA, IL1B, TNFAIP3, BIRC3

GO:0043069

negative regulation of programmed cell death

8.15*10−5

CSF2, IER3, IL6, MCL1, HIPK3, NFKBIA, IL1B, TNFAIP3, BIRC3

GO:0060548

negative regulation of cell death

8.31*10−5

CSF2, IER3, IL6, MCL1, HIPK3, NFKBIA, IL1B, TNFAIP3, BIRC3

GO:0006915

apoptosis

1.15*10−4

TRAF1, RNF144B, IER3, IL6, MCL1, HIPK3, NFKBIA, IL1B, ZC3H12A, TNFAIP3, BIRC3