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Figure 2 | Cell Communication and Signaling

Figure 2

From: Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy

Figure 2

Disruption of the Hsp20-PKD1 complex attenuates hypertrophic signaling in neonatal cardiac myocytes. A. A cell permeable disruptor peptide (DIS), but not scrambled control (CTR), ablates interaction of PKD1 and Hsp20 in cardiac myocytes. B. and C. The Hsp20-PKD1 disruptor peptide reduces cardiac myocyte cell size following chronic β-adrenergic (isoprenaline; ISO) stimulation. D. The Hsp20-PKD1 disruptor peptide reduces relative protein/DNA ratio of cells following chronic β-adrenergic stimulation (n = 9). E. The Hsp20-PKD1 disruptor peptide reduces the expression of hypertrophic markers atrial natruiretic peptide (ANP), brain natruiretic peptide (BNP) and β-myosin heavy chain (β-MHC) following chronic β-adrenergic stimulation (n = 7). F. The Hsp20-PKD1 disruptor peptide reduces actin cytoskeletal rearrangement following chronic β-adrenergic stimulation. Data representative of n = 3 independent experiments.

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