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Figure 6 | Cell Communication and Signaling

Figure 6

From: Immune checkpoint regulator PD-L1 expression on tumor cells by contacting CD11b positive bone marrow derived stromal cells

Figure 6

Model of PD-L1 induction on tumor cells by CD11b-positive BM. BM cells adhere to the surface of tumor cells through CD11b interaction with an unknown receptor on the tumor cell surface. This interaction activates the p38 signaling pathway and induces PD-L1 expression, both intracellular and on the tumor cell surface. Overexpressed PD-L1 may play a role in metastasis, immune evasion, and drug resistance.

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