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Figure 4 | Cell Communication and Signaling

Figure 4

From: Chronic myeloid leukemia-derived exosomes promote tumor growth through an autocrine mechanism

Figure 4

CML Exosomes Trigger the in Vitro and in Vivo Activation of ERK/ Akt/ NF-Kb Pathways. (a) Western blot analysis shows that treatment of LAMA84 with 10 μg/ml of LAMA84 exosomes for 72 or 96 hours triggers the phosphorylation of ERK and Akt without altering the total level of these proteins, and increases the expression of NF-kB. (b) A comparable effect can be observed in CML xenografts treated or not with exosomes.

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