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Figure 2 | Cell Communication and Signaling

Figure 2

From: Chronic myeloid leukemia-derived exosomes promote tumor growth through an autocrine mechanism

Figure 2

Anti-Apoptotic and Pro-Survival Effect of CML-Derived Exosomes on Gene Expression. (a) Real-time PCR analysis shows that treatment of LAMA84 with LAMA84 exosomes up to 1 week increases the mRNA expression of the anti-apoptotic genes survivin, BCL-xl, and BCL-w, while it decreases the mRNA levels of the pro-apoptotic genes BAD, BAX and PUMA. (b) Similar effects were observed in samples from mice treated with exosomes compared with control mice, treated with PBS (black bar). Asteriks indicate a significant difference in comparison to control (Ctrl) (**p ≤ 0.01; *** p ≤ 0.001).

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