Skip to main content
Figure 3 | Cell Communication and Signaling

Figure 3

From: TNF-α and IGF1 modify the microRNA signature in skeletal muscle cell differentiation

Figure 3

Functional analysis of miRNAs in human myoblast differentiation and TNF-α treatment. Relative fusion indices for miRNA mimics or miRNA inhibitor transfections into human LHCN myoblasts in the differentiation medium (black bars) or differentiation medium with TNF-α supplementation (grey bars). (A) Transfection of 25 nM miRNA mimics or scrambled control miRNA (scrbl), (B) 50 nM miRNA inhibitors or scrambled control inhibitors (anti-scrbl), and (C) a combination of 75 nM miRNA inhibitor and 25 nM miRNA mimic or respective controls. Samples with specific miRNAs or inhibitors are shown relative to the respective scrambled reference which was set to 100% fusion index. Significant differences (p > 0.05) of relative fusion indices are marked by an asterisk.

Back to article page