Figure 5From: Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activationHypertrophic effect of succinate in cardiomyocytes requires GPR91 expression. A. Real time PCR showed significant knockdown of GPR91 mRNA levels in cells transfected with siRNA against GPR91 (n = 3 independent experiments, ***p < 0.001). B-C. Knockdown of GPR91 decreased ANP and BNP mRNA levels. (***p < 0.001).Back to article page