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Figure 1 | Cell Communication and Signaling

Figure 1

From: The structure function of the death domain of human IRAK-M

Figure 1

3D structure model of the human IRAK-M death domain (DD). (A) Model of the DD of human IRAK-M (Blue) superimposed on the template DD structure 2A9I (Orange) of mIRAK-4 and sequence alignment of hIRAK-M-DD and mIRAK-4-DD. The sequence identity is 28.7%. Secondary structures such as alpha-helices and beta-strands of mIRAK-4-DD (2A9I) are indicated underneath the sequences (Red bar: alpha-helix: Purple bar: unstable helix; Green arrow: beta-strand). (B) Interactive surface prediction of hIRAK-M-DD. Space filling model with predicted interactive residues in red that form two patches. (C) The predicted interactive residues in the two patches which were mutated in this study are shown with side chain and residue number in the back bone model in red and blue.

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