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Figure 5 | Cell Communication and Signaling

Figure 5

From: The T-box transcription factor Brachyury promotes renal interstitial fibrosis by repressing E-cadherin expression

Figure 5

Brachyury expression is induced in the fibrotic kidney. (A) Immunohistochemical analysis for TGF-β1, Brachyury, vimentin and E-cadherin in the kidney tissue of UUO rats and sham-operated rats. The tubule interstitial fibrosis was analyzed using a Masson’s trichrome staining kit. Original magnification × 400. (B) Western blot analyses revealed the induction of Brachyury protein in the fibrotic kidney. Samples from two representative animals were used at each time point. A representative blot from three independent experiments is shown (left). Relative Brachyury protein levels (fold induction over the sham control) after correction with actin are presented (right).

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Cell Communication and Signaling

ISSN: 1478-811X