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Figure 4 | Cell Communication and Signaling

Figure 4

From: Selective targeting of transforming growth factor-beta1 into TCR/CD28 signalling plasma membrane domains silences T cell activation

Figure 4

A, B Cytokine array of human pan T cell cytokine secretion-profiles. A) TCR/CD28 activating-antibodies on anti-CD3/CD28/LAP beads induced cytokine secretion (black bars) over non-activating control beads (white bars). Loading of TGFβ1-LAP on these TCR/CD28 activating beads suppressed activation-induced secretion of cytokines in a dose-dependent manner (grey bars). B) Cytokines which were secreted by resting T cells showed little induction following TCR-activation were not affected by TGFβ1 on TCR/CD28 activating beads. The cytokine array analysis was performed once and is detailed in Additional file 2: Figure S2.

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Cell Communication and Signaling

ISSN: 1478-811X