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Figure 2 | Cell Communication and Signaling

Figure 2

From: Selective targeting of transforming growth factor-beta1 into TCR/CD28 signalling plasma membrane domains silences T cell activation

Figure 2

A, B Selective targeting of TGFβ1 into TCR/CD28 activation sites attenuates T cell proliferation response. A) TGFβ1-LAP, when presented to human T lymphocytes by anti-LAP- (grey triangles) or anti-LAP/CD28- (white squares) antibody-coated protein G beads, does not inhibit proliferative response elicited by separate anti-CD3/CD28 antibody-coated beads (n = 3). TGFβ1-LAP presented on anti-CD3/CD28/LAP beads (black circles) effectively held back proliferation (n = 4). B) Soluble TGFβ1, as latent TGFβ1-LAP (black circles) or active TGFβ1 cytokine (white squares), was present in equimolar amounts as TGFβ1-LAP for Figures 1A, 2A and did not effectively hold back T cell proliferation induced by activating anti-CD3/CD28 beads.

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Cell Communication and Signaling

ISSN: 1478-811X