Figure 6From: Alteration in mitochondrial Ca2+ uptake disrupts insulin signaling in hypertrophic cardiomyocytesProposed model for insulin-induced mitochondrial Ca2+uptake in normal and hypertrophic cardiomyocytes. During hypertrophy there is a decrease in ER-mitochondria physical coupling, disrupting Ca2+ transfers between both organelles, thus leading a diminished Akt phosphorylation and oxygen consumption in response to insulin.Back to article page