Skip to main content

Table 1 Response properties and gain analysis for rods from WT and GARP2 tg mice

From: Overexpression of rod photoreceptor glutamic acid rich protein 2 (GARP2) increases gain and slows recovery in mouse retina

  Genotype (n) Rmax I1/2(R*) spr Ti(ms) Tp(ms) τD(ms) Gain (s-2)
Live ERG WT (8) 585 ± 158 μV       6.7 ± 0.6*
  tg (7) 398 ± 93 μV       13.9 ± 1.4*
Tissue ERG WT (21) 241 ± 25 μV 55 ± 5     99 ± 5 * 3.5 ± 0.5*
  tg (14) 181 ± 26 μV 59 ± 9     167 ± 17* 6.6 ± 0.7*
Single cell WT (29) 12.6 ± 0.7 pA 21.7 ± 1.5* 0.45 ± 0.02 312 ± 17 152 ± 6* 160 ± 6.9* 7.9 ± 0.6 (n = 20)*
  tg (13) 11.2 ± 0.6 pA 13.0 ± 2.0* 0.42 ± 0.05 277 ± 24 131 ± 5* 209 ± 11.5* 16.5 ± 2.2*
  1. *Indicates significance (p < 0.05).
  2. Criterion for inclusion in the data set was a maximum response (Rmax) of at least 7 pA. Phototransduction gain analysis only includes cells whose single photon response had been determined, thus defining the collecting area of the cell (see Methods). Values are shown as mean ± SEM. Labels are, half-maximal intensity, (I1/2), single photon response amplitude (spr), Integration time (Ti), time-to-peak of linear range responses (Tp), dominant time constant of recovery, (τD), and phototransduction gain (Gain).
  3. t-test p-values:
  4. (WT vs tg) Single cell gain: 0.0000484 Single cell τD: 0.000365 Tp: 0.0267.
  5. Tissue gain: 0.000695 Tissue τD: 0.0000658.