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Table 1 Response properties and gain analysis for rods from WT and GARP2 tg mice

From: Overexpression of rod photoreceptor glutamic acid rich protein 2 (GARP2) increases gain and slows recovery in mouse retina

 

Genotype (n)

Rmax

I1/2(R*)

spr

Ti(ms)

Tp(ms)

Ï„D(ms)

Gain (s-2)

Live ERG

WT (8)

585 ± 158 μV

     

6.7 ± 0.6*

 

tg (7)

398 ± 93 μV

     

13.9 ± 1.4*

Tissue ERG

WT (21)

241 ± 25 μV

55 ± 5

   

99 ± 5 *

3.5 ± 0.5*

 

tg (14)

181 ± 26 μV

59 ± 9

   

167 ± 17*

6.6 ± 0.7*

Single cell

WT (29)

12.6 ± 0.7 pA

21.7 ± 1.5*

0.45 ± 0.02

312 ± 17

152 ± 6*

160 ± 6.9*

7.9 ± 0.6 (n = 20)*

 

tg (13)

11.2 ± 0.6 pA

13.0 ± 2.0*

0.42 ± 0.05

277 ± 24

131 ± 5*

209 ± 11.5*

16.5 ± 2.2*

  1. *Indicates significance (p < 0.05).
  2. Criterion for inclusion in the data set was a maximum response (Rmax) of at least 7 pA. Phototransduction gain analysis only includes cells whose single photon response had been determined, thus defining the collecting area of the cell (see Methods). Values are shown as mean ± SEM. Labels are, half-maximal intensity, (I1/2), single photon response amplitude (spr), Integration time (Ti), time-to-peak of linear range responses (Tp), dominant time constant of recovery, (τD), and phototransduction gain (Gain).
  3. t-test p-values:
  4. (WT vs tg) Single cell gain: 0.0000484 Single cell Ï„D: 0.000365 Tp: 0.0267.
  5. Tissue gain: 0.000695 Tissue Ï„D: 0.0000658.
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Cell Communication and Signaling

ISSN: 1478-811X