| Genotype (n) | Rmax | I1/2(R*) | spr | Ti(ms) | Tp(ms) | τD(ms) | Gain (s-2) |
---|
Live ERG
| WT (8) | 585 ± 158 μV |  |  |  |  |  | 6.7 ± 0.6* |
 | tg (7) | 398 ± 93 μV |  |  |  |  |  | 13.9 ± 1.4* |
Tissue ERG
| WT (21) | 241 ± 25 μV | 55 ± 5 |  |  |  | 99 ± 5 * | 3.5 ± 0.5* |
 | tg (14) | 181 ± 26 μV | 59 ± 9 |  |  |  | 167 ± 17* | 6.6 ± 0.7* |
Single cell
| WT (29) | 12.6 ± 0.7 pA | 21.7 ± 1.5* | 0.45 ± 0.02 | 312 ± 17 | 152 ± 6* | 160 ± 6.9* | 7.9 ± 0.6 (n = 20)* |
 | tg (13) | 11.2 ± 0.6 pA | 13.0 ± 2.0* | 0.42 ± 0.05 | 277 ± 24 | 131 ± 5* | 209 ± 11.5* | 16.5 ± 2.2* |
- *Indicates significance (p < 0.05).
- Criterion for inclusion in the data set was a maximum response (Rmax) of at least 7 pA. Phototransduction gain analysis only includes cells whose single photon response had been determined, thus defining the collecting area of the cell (see Methods). Values are shown as mean ± SEM. Labels are, half-maximal intensity, (I1/2), single photon response amplitude (spr), Integration time (Ti), time-to-peak of linear range responses (Tp), dominant time constant of recovery, (τD), and phototransduction gain (Gain).
- t-test p-values:
- (WT vs tg) Single cell gain: 0.0000484 Single cell Ï„D: 0.000365 Tp: 0.0267.
- Tissue gain: 0.000695 Tissue Ï„D: 0.0000658.