Figure 4
Analysis of phototransduction gain in live mice. (A) An example fit of the rising phase of the a-wave in ERG responses in WT mice for a range of 1,400-44,000 photon/μm2 incident at the cornea. Individual electrophysiological responses are shown in black with the global gain fits overlaid in red. (B) Example fit of the rising phase of the a-wave in ERG responses to a flash range of 2,300-52,000 photons/μm2 incident at the cornea in a tg mouse. Individual electrophysiological responses are shown in red with the global gain fits overlaid in black. (C) Response amplitudes for flashes of 48,000 photons/μm2 incident at the cornea were normalized to the Rmax for each individual animal to illustrate the difference in the rising phase of the a-wave. WT (black, n = 8) and tg (red, n = 7).