Figure 2

Selectivity profile of BDP5290. The percentage inhibition of 36 kinases by 10 μM BDP5290 was mapped onto the kinome phylogenetic tree. Kinases inhibited less than 25% have their names in green text. Kinases inhibited >25% and ≤50% have yellow circles, >50% and ≤75% have orange circles, and >75% have red circles. In each case, the size of the circle is proportional to the percentage inhibition. ROCK1 and MRCKβ positions are indicated on the tree for orientation purposes. Illustration reproduced courtesy of Cell Signaling Technology, Inc. (www.cellsignal.com).