Figure 1
From: A novel small-molecule MRCK inhibitor blocks cancer cell invasion
Structure of BDP5290 and in vitro kinase inhibition profiles. (A) Structure of 4-chloro-1-(4-piperidyl)-N-[5-(2-pyridyl)-1H-pyrazol-4-yl]pyrazole-3-carboxamide (BDP5290). (B) BDP5290 dose–response curves for inhibition of MRCKβ, ROCK1 and ROCK2 kinase activity in vitro at 1 μM ATP. (C) Y27632 dose–response curves for inhibition of MRCKβ, ROCK1 and ROCK2 kinase activity in vitro at 1 μM ATP. All results are shown as mean ± standard error of n ≥ 4 independent replicates.