Figure 5

Expression of genes in the Th1 response network and interferon signaling pathway. (A) Interaction and expression of Th1 response genes in the wild type H99-infected animals. (B) Interaction and expression of Th1 response genes in the itr1aΔ itr3cΔ mutant-infected animals. (C) Interaction and expression of canonical interferon signaling pathway genes in the mutant-infected animals. Shapes in red are up-regulated and green are down-regulated. Intensity of the shape colors is relative to the level of gene expression (dark color denotes stronger expression). Solid lines represent direct interaction and broken lines show indirect interactions. The legend is common for (A), (B) and (C).