Figure 5
From: TCR-triggered extracellular superoxide production is not required for T-cell activation
Extracellular superoxide production is not required for cytokine release by human CD4 + T cells. Human naïve CD4+ T cells were stimulated with CD3xCD28-coated microbeads alone or in the presence of either SOD, catalase or ascorbate. After 48 hours, supernatants were collected. Cytokine concentrations were measured using Bio-Plex Pro assay. The values indicate the cytokine concentrations normalized to stimulated controls. The data show the mean from 3 independent experiments.