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Figure 9 | Cell Communication and Signaling

Figure 9

From: AhR and Arnt differentially regulate NF-κB signaling and chemokine responses in human bronchial epithelial cells

Figure 9

AhR- activation suppresses Poly I: C- induced CXCL8 and CCL5 responses, but stimulate CXCL8 responses alone in BEAS- 2B cells. Cells were incubated with 1 μM of the AhR agonist β-naphtoflavone (BNF) for 30 min prior to exposure to 10 μg/ml Poly I:C for 18 h (A and B), or exposed to high concentrations of ANF or BNF alone for 18 h (C and D). CXCL8 (A and C) and CCL5 (B and D) levels in the medium were measured by ELISA as described under “Materials and methods”. The results are expressed as mean ± SEM (n = 3). *Significant increase induced by Poly I:C; †Significant reduction induced by BNF.

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Cell Communication and Signaling

ISSN: 1478-811X