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Figure 10 | Cell Communication and Signaling

Figure 10

From: AhR and Arnt differentially regulate NF-κB signaling and chemokine responses in human bronchial epithelial cells

Figure 10

The constitutive activity of unligated AhR and Arnt differentially regulate CXCL8 and CCL5 in BEAS- 2B cells. The model summarizes the possible pathways discussed for AhR- and Arnt-mediated regulation of CXCL8 and CCL5 in BEAS-2B cells exposed to 1-NP and 1-AP (A) or Poly I:C (B). “x/X” and “y/Y” represents hitherto unidentified signaling pathways/response elements involved in regulation of CXCL8 and CCL5, respectively. The positioning of the response elements in the CXCL8 or CCL5 promoters is not meant to be representative. Moreover, “y/Y” induced by 1-AP (A) and Poly I:C (B) are not necessarily identical and AhR may also affect other pathways involved in Poly I:C-induced CXCL8 in addition to NF-κB (B). The suggested position and association of Arnt and RelB is partly based on findings reported by Wright and Duckett [49]. The role of AhR and Arnt in chemokine regulation may differ in other cell types.

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